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Potential adverse effects of testosterone replacement therapy. The estimated likelihood of adverse effects of long-term TRT is still essentially unknown, as overall high-quality evidence to recommend against its use in most men with TD is lacking.
1 Ιουν 2010 · In 2005, a meta-analysis of the adverse effects of testosterone replacement therapy ( 6) showed that elevated hematocrit and an increase in a composite of prostate-related events were the most common side effects of testosterone replacement therapy.
8 Ιουλ 2010 · The effects of testosterone therapy on efficacy outcomes are reported briefly. Methods. Study Design. The TOM trial was a parallel-group, randomized, placebo-controlled, double-blind trial...
26 Αυγ 2020 · More than one-third of men with obesity and either type 2 diabetes (T2D) or metabolic syndrome (MetS) exhibit lowered testosterone levels [1–5]. Functional hypogonadism (FH) is caused by conditions...
1 Φεβ 2024 · Generally, the use of short-acting TT causes several side effects including polycythemia, gynecomastia, suppression of spermatogenesis, and impaired fertility, though these are also side effects of long-acting TT 21,22. However, it is difficult to interpret the impact of short-acting TT on sperm parameters, as the misuse of TT for male ...
Current literature supports that TRT does not substantially worsen lower urinary tract symptoms, and may actually improve symptoms in some men. Limited evidence suggests that TRT may initially worsen obstructive sleep apnea in some men, but that this is not a longstanding effect.
We recommend testosterone therapy in hypogonadal men to induce and maintain secondary sex characteristics and correct symptoms of testosterone deficiency. (1 ⊕⊕⊕O) • Lack of long-term RCT data on the effects of TRT on MACE and prostate cancer led to a more guarded “suggestion” in older men.
