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18 Ιουλ 2008 · MEN1 gene mutations can be identified in 70-95% of MEN1 patients. Many endocrine tumors in MEN1 are benign and cause symptoms by overproduction of hormones or local mass effects, while other MEN1 tumors are associated with an elevated risk for malignancy.
- Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer
MENIN is a scaffold protein encoded by the MEN1 gene that...
- Multiple Endocrine Neoplasia Type 1 - GeneReviews® - NCBI Bookshelf
Multiple endocrine neoplasia type 1 (MEN1) is characterized...
- Multiple Endocrine Neoplasia Type 1 - NIDDK
MEN1 is an inherited disorder most often caused by a...
- Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer
14 Σεπ 2020 · MENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, gene expression, and DNA damage repair. MEN1 is a tumor suppressor gene, and mutations that disrupts MEN1 function are common to many tumor types.
31 Αυγ 2005 · Multiple endocrine neoplasia type 1 (MEN1) is characterized by varying combinations of more than 20 endocrine and non-endocrine tumors. Endocrine tumors occurring in individuals with MEN1 are shown in Table 2.
14 Φεβ 2024 · MEN 1 is caused by a change in the MEN1 gene. That gene controls how the body makes a protein called menin. Menin helps to keep cells in the body from growing and dividing too quickly.
MEN1 is an inherited disorder most often caused by a mutation in the MEN1 gene. The gene provides instructions for producing a protein called menin, known to play a role in keeping cells from growing and dividing too fast.
People with multiple endocrine neoplasia type 1 are born with one mutated copy of the MEN1 gene in each cell. [6] [3] Then, during their lifetime, the other copy of the gene is mutated in a small number of cells.
1 Σεπ 2012 · MEN1 is an autosomal dominant disorder that is due to mutations in the tumor suppressor gene MEN1, which encodes a 610-amino acid protein, menin.
