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22 Ιουν 2011 · The transverse tubules (t-tubules) are invaginations of the cell membrane rich in several ion channels and other proteins devoted to the critical task of excitation–contraction coupling in cardiac muscle cells (cardiomyocytes).
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rate). For example, the mouse, which has a heart rate of...
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16 Μαΐ 2022 · Here, we provide a complete morphological description of mammalian heart tube formation based on detailed imaging of a temporally dense collection of mouse embryonic hearts.
T-tubule membrane contains microdomains that compartmentalize transmembrane ion handling proteins and signaling molecules. Together, t-tubules are effective organelles that serve as a centralized signaling hub controlling cardiac contractile function and electrophysiology.
11 Μαρ 2021 · Here, we show that microtubules are indispensable for cardiac growth via spatiotemporal control of the translational machinery. We find that the microtubule motor Kinesin-1 distributes mRNAs...
23 Οκτ 2016 · Sinoatrial node myocytes (SAMs) act as the natural pacemakers of the heart, initiating each heart beat by generating spontaneous action potentials (APs). These pacemaker APs reflect the coordinated activity of numerous membrane currents and intracellular calcium cycling.
1 Ιαν 2021 · Types and topologies of cellular tubes. Tubular structures can be classified according to their cellular organization as (i) multicellular tubes, (ii) unicellular or autocellular tubes, and (iii) seamless or subcellular tubes.
31 Ιουλ 2021 · In this manuscript, we described a straightforward method of isolating adult mouse cardiomyocytes using Langendorff perfusion apparatus. Briefly, the hearts were harvested from adult mice and the heart was mounted to Lagendorff apparatus.
