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9 Σεπ 2011 · The transverse tubules (t-tubules) are invaginations of the cell membrane rich in several ion channels and other proteins devoted to the critical task of excitation–contraction coupling in cardiac muscle cells (cardiomyocytes).
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Mechanical load alters t-tubule structure. Both mechanical...
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The system is continuous across the fiber at the H band...
- Orphaned Ryanodine Receptors in The Failing Heart
Ca 2+ sparks, the elementary Ca 2+ release events during the...
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23 Οκτ 2016 · Abstract. Sinoatrial node myocytes (SAMs) act as the natural pacemakers of the heart, initiating each heart beat by generating spontaneous action potentials (APs). These pacemaker APs reflect the coordinated activity of numerous membrane currents and intracellular calcium cycling.
10 Οκτ 2020 · In order to investigate the therapeutic role and molecular mechanism of these cardiokines during heart repair and regeneration, a prolonged culture is required. Adult rat CMs are robust enough for single-cell isolation and long-term culture in an in vitro system 10, 11, 12.
16 Μαΐ 2022 · Here, we provide a complete morphological description of mammalian heart tube formation based on detailed imaging of a temporally dense collection of mouse embryonic hearts.
This review summarizes and cites the current knowledge of cardiac t-tubule morphology, structure, components, and physiological functions, with emphasis on the organization and function of microdomains within t-tubules.
1 Ιουλ 2022 · Abstract. Cardiac fibroblasts play a critical role in extracellular matrix homeostasis, wound healing, and cardiac interstitial fibrosis: the latter being a pathophysiological response to a chronic increase in afterload.
31 Ιουλ 2021 · This means that cell numbers gradually diminish in culture. Therefore, establishing a protocol for isolating high-quality and quantity cardiomyocytes is critical for studying adult cardiac function. Langendorff perfusion system has been the centerpiece for cardiomyocyte isolation for over 45 years . However, the protocols used by different ...
