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10 Ιουλ 2020 · The pivotal phase 3 study (NCT03252431) evaluating efbemalenograstim alpha (F-627) as treatment of chemotherapy-induced neutropenia in patients with breast cancer met both the primary and secondary end points, Evive Biotech announced in a press release.
31 Μαρ 2021 · A biologics license application has been submitted to the FDA for the approval of F-627 (Ryzneuta; formerly efbemalenograstim alpha) as a treatment option for patients with breast cancer who...
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19 Νοε 2010 · In a cyclophosphamide-induced neutropenia monkey model, F-627 significantly reduced the duration and lessened the severity of neutropenia compared to monkeys treated with G-CSF or pegylated G-CSF. We report the phase I results of F-627 in healthy male subjects receiving ascending single dose at 30, 60, 120 and 240 ug/kg by subcutaneous injection.
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