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9 Ιουλ 2020 · Efbemalenograstim alpha (F-627) has demonstrated strong and durable benefit when used as a treatment for chemotherapy-induced neutropenia in patients with breast cancer, meeting the primary and...
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31 Μαρ 2021 · A biologics license application has been submitted to the FDA for the approval of F-627 (Ryzneuta; formerly efbemalenograstim alpha) as a treatment option for patients with breast cancer who...
23 Νοε 2021 · F-627 was well tolerated, with a low incidence of serious AEs and AEs leading to discontinuation, comparable to the profile for Neulasta®. There were 3 deaths during the study (1 for F-627 and 2 for Neulasta®). None of the deaths were related to study drug treatment.
19 Νοε 2010 · In a cyclophosphamide-induced neutropenia monkey model, F-627 significantly reduced the duration and lessened the severity of neutropenia compared to monkeys treated with G-CSF or pegylated G-CSF. We report the phase I results of F-627 in healthy male subjects receiving ascending single dose at 30, 60, 120 and 240 ug/kg by subcutaneous injection.
A Phase II, Randomized, Multi-Centre, Open-Label, Active-Controlled, Dose-Finding Trial of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy. Status:Completed. Phase of Trial: Phase II. Latest Information Update:29 Jan 2024. Price : $35 *.
22 Ιουλ 2023 · Counts primarily reflect laboratory-confirmed cases and deaths, based upon WHO case definitions; although some departures may exist due to local adaptations. Counts include both domestic and repatriated cases.
