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This protocol is part of the AC-TH regimen: 4 cycles of AC, followed by 4 cycles of TH and 13 cycles of trastuzumab. Link to Breast adjuvant AC-TH overview; Link to Breast adjuvant AC (DOXOrubicin and CYCLOPHOSPHamide) three weekly; Drug status: Docetaxel is on the PBS general schedule. Trastuzumab is PBS authority
14 Δεκ 2023 · Amplification or overexpression of the human epidermal growth factor receptor 2 (HER2) oncogene is present in approximately 15 percent of primary invasive breast cancers [1]. Women with early-stage breast cancer that meet criteria for HER2 positivity are treated with chemotherapy and trastuzumab as adjuvant treatment.
7 Δεκ 2022 · The following material represents a subset of chemotherapy and immunotherapy regimens that are used for the treatment of patients with breast cancer, both in the adjuvant and neoadjuvant settings.
1 Μαΐ 2018 · Dose-Dense AC is repeated every 2 weeks or 14 days. This is known as one Cycle and is repeated for a total of 4 cycles. During TH treatment, paclitaxel is given every 14 days and trastuzumab is given once a week for the first eight weeks. Then, trastuzumab is given alone every 21 days for 44 weeks.
26 Απρ 2016 · In patients age 65 years or older, capecitabine is not recommended as an adjuvant chemotherapy option in lieu of standard regimens like doxorubicin plus cyclophosphamide (AC) or cyclophosphamide, methotrexate, and fluorouracil (CMF [with oral cyclophosphamide]). CMF As an Alternative to AC.
3 Μαΐ 2018 · Adjuvant chemotherapy has greatly improved the prognosis of early breast cancer. Dose-dense chemotherapy seeks to increase efficacy by changing the interval between cycles of treatment without the need of increasing doses and toxicity.
EXCLUSIONS: Pregnancy. Significant cardiovascular disease and/or LVEF less than 50%; if initial reading is less than 50%, physician may consider repeating for validity, or assessing LVEF by the other modality, e.g. echocardiogram instead of MUGA. Known hypersensitivity to E. coli derived products.
