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11 Ιουλ 2024 · Alveolar hypoventilation, defined as an elevation in PaCO₂ to levels >45 mmHg, can occur with several disorders: obesity hypoventilation syndrome, restrictive thoracic disorders, central sleep apnea syndromes, and COPD.
Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate (hypo meaning "below") to perform needed respiratory gas exchange. [1] By definition it causes an increased concentration of carbon dioxide (hypercapnia) and respiratory acidosis.
Chronic alveolar hypoventilation, defined as a sustained increase in PCO 2 exceeding 45 mm Hg, is a condition commonly encountered by the chest physician.
Alveolar hypoventilation is defined as insufficient ventilation, resulting in both an increase in Paco2 and a decrease in Pao2. This is the major mechanism of nocturnal impairment in gas exchange.
1 Δεκ 2008 · Central alveolar hypoventilation disorders are rare and complex disorders that may involve alterations in mechanisms of ventilatory control and autonomic dysfunction. These disorders may be congenital or acquired and are associated with significant morbidity and mortality.
A diagnosis of OHS commonly requires awake alveolar hypoventilation (PaCO 2 >45 mm Hg) in an obese patient (body mass index [BMI; body weight divided by height squared] >30 kg/m 2; other investigators have used >35 kg/m 2) with no other identifiable cause of hypoventilation. 22.
Hypoventilation syndrome comprises disorders associated with alveolar hypoventilation (an elevation in PaCO₂ to levels >45 mmHg). Hypoxemia is also present in most cases, especially during sleep (PaO₂ <60 mmHg).
