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  1. 10 Ιουλ 2018 · The results, published in Frontiers in Physiology, demonstrate the advantages of using computer simulations over animal models in early drug trials, and the improvements these approaches can make to drug safety. Using animal models to test new drugs is a crucial component of almost every drug trial.

  2. Various alternatives to animal use have been suggested, which need to be implemented in an effective manner. For this integration of various computer models, bioinformatics tools, in vitro cell cultures, enzymatic screens and model organisms are necessary. Use of modern analytical techniques, data acquisition and statistical procedures to ...

  3. 29 Οκτ 2020 · In silico modelling, in vitro assays, high-throughput screening, organ-on-a-chip technology, omics and mathematical biology, can provide complementary information to develop a complete picture of the potential response of an organism to a chemical stressor.

  4. In silico modelling, in vitro assays, high-throughput screening, organ-on-a-chip technology, omics and mathematical biology, can provide complementary information to develop a complete picture of the potential response of an organism to a chemical stressor.

  5. 14 Ιαν 2019 · Can the computer eliminate the lab animal? As computational methods become more advanced and data more freely available, in silico modeling approaches have growing potential to help reduce...

  6. 1 Ιουλ 2015 · Various alternatives to animal use have been suggested, which need to be implemented in an effective manner. For this integration of various computer models, bioinformatics tools, in vitro cell cultures, enzymatic screens and model organisms are necessary. Use of modern analytical techniques, data acquisition and statistical procedures to ...

  7. 7 Computational Systems Biology, Zuse Institute Berlin, Germany. 8 Department of Mathematics and Computer Science, Freie Universität Berlin, Germany. 9 German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany. 10 Biomechanics Research Unit, University of Liège, Belgium ...

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