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23 Σεπ 2021 · Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
Timing of levels: Draw trough 30 min prior to 4th dose. Draw peak 30 min after infusion ends Once daily dosing: goal peak 35 – 60 mcg/mL; goal trough < 4 mcg/mL Conventional dosing: goal peak 25 – 35 mcg/mL for serious infections; 15 – 20 mcg/mL for UTI; goal trough < 4 – 8 mcg/mL.
Peak and trough blood levels are monitored for some antibiotics to determine how a client’s body is responding to an antimicrobial. Dosing is then tailored to the individual based on peak and trough levels.
follow peak and trough levels. Check levels after second or third dose. Target peak level (30 minutes after dose): Pneumonia: 7-8 mg/dL. Other systemic gram-negative infections: 6-8 mg/L. Endocarditis: 3-4 mg/L. (26373316, 26320109) Cystitis: 3-4 mg/L. (UVM Green Book) Target trough level: <1 mg/L.
Follow up trough level testing • An early trough (6-hours prior to dose) should be considered in patients demonstrating acute changes in renal function or suspicion of extended interval failure.
22 Φεβ 2023 · Trough-based protocol Trough 15-20 mg/L • In general, goal AUC/MIC ≥ 400 for S.aureus • Monitor closely with trough > 15 or AUC > 650: increased risk of nephrotoxicity
Welcome to the ELHT Antimicrobial Formulary! It is hoped that this tool will help promote the safe, effective and economic use of antibiotics across ELHT, minimise the emergence of bacterial resistance and provide more accesible & support for prescribers across the Trust. V1.1 Changelog.
