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Understanding drug pharmacokinetics (PK) and pharmacodynamics (PD) is essential when determining the most effective antibiotic therapy. In addition, successful antimicrobial therapy requires appropriate choice of antibiotic, including dose, frequency, and duration (Figure 1). Figure 1.
Successful antibiotic treatment is based on 4 principles: 1) identifying the disease-causing agent and selecting the appropriate drug for treatment; 2) attaining effective concentrations of the drug at the site of infection for a sufficient period of time; 3) choosing a dose rate, frequency, and method of administering the dose that maximizes ...
In a murine model, treatment with gentamicin and a fluoroquinolone markedly lowers bacterial counts, compared to treatment with beta-lactam antimicrobials, indicating that the rapid killing of bacteria is important in the treatment of UTI.
The antimicrobial therapy should last for 10 days to 2 weeks. Complicated infection (relapse / persistent, reinfection and superinfection) --based on urine culture and choose antimicrobial according to high renal and urinary excretion, no nephrotoxicity, and side effects.
27 Ιουν 2011 · Treatment should be initiated immediately, while awaiting culture and susceptibility results. Initial treatment should involve antimicrobial drugs known to have local or regional efficacy against Gram-negative Enterobacteriaceae, based on the predominance of those organisms in pyelonephritis. If regional data are supportive, treatment with a ...
A fluoroquinolone or a combination of a fluoroquinolone with a β-lactam antibiotic is often effective. Dosages should be the same as for other soft-tissue infections. Animals that are febrile, anorectic, dehydrated, or azotemic should be hospitalized to provide IV antibiotics and fluid therapy.
Urinary tract disease is a common reason for use (and likely misuse, improper use, and overuse) of antimicrobials in dogs and cats. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine.
