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HIV treatment. AZT was usually dosed twice a day in combination with other antiretroviral therapies. This approach is referred to as Highly Active Antiretroviral Therapy (HAART) and is used to prevent the likelihood of HIV resistance. [12][13] As of 2019, the standard is a three-drug once-daily oral treatment that can include AZT. [14]
AZT, drug used to delay development of AIDS (acquired immunodeficiency syndrome) in patients infected with HIV (human immunodeficiency virus). AZT belongs to a group of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs).
19 Μαρ 2017 · The first AIDS drug was approved on March 19, 1987—but getting there was by no means easy. Here's the story behind the treatment.
AZT: The First Drug to Treat HIV Infection. Scientists funded by NIH’s National Cancer Institute (NCI) first developed azidothymidine (AZT) in 1964 as a potential cancer therapy. AZT proved ineffective against cancer and was shelved, but in the 1980s, it was included in an NCI screening program to identify drugs to treat HIV/AIDS.
The discovery of the broad antiretroviral properties of a series of 2′,3′-dideoxynucleosides, the most prominent of which is AZT (3′-azido-2′,3′-dideoxythymidine, zidovudine), showed that treating HIV-1 was possible.
It can be efficiently used to prevent motherto- child transmission of HIV, to treat HIV infection (in particular, in patients with concomitant chronic viral hepatitis), and to prevent healthcare-worker infections.
AZT became the world’s first antiretroviral therapy, targeting one key enzyme in HIV’s cellular takeover strategy. The treatment was developed and marketed by Burroughs Wellcome, which became part of the firm now known as GSK.
