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The current article aims to focus on past and present work done on BA derivatives and to emphasize the molecular pathways involved in cancer treatment. The future prospects for research in this area are encouraging as researchers are striving to advance synthetic BA derivatives.
29 Ιουλ 2020 · The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus.
29 Μαΐ 2023 · During the process of looking for new chemical entities, it was found that certain compounds with a basic nucleus of benzoic acid (BA) exhibit a remarkable anticancer potential.
The most recommended conventional cancer treatment strategies include surgical resection of the tumors followed by radiotherapy with x-rays and/or chemotherapy. 11 Of these modalities, surgery is most effective at an early stage of disease progression. Radiation therapy can damage healthy cells, organs, and tissues.
21 Νοε 2020 · The cytotoxic activity was evaluated against breast carcinoma (MCF-7), lung cancer (A549), human prostate cancer (PC-3), human pancreatic cancer (PaCa2), and colorectal adenocarcinoma (HT-29) cell lines.
In summary, analysis of in silico docking studies, in vitro and ex vivo studies identified DHBA as a potent HDAC inhibitor compared with benzoic acid or other benzoic acid derivatives. Mechanistically, DHBA induced cancer cell death is mediated by (a) elevated caspase-3 and reactive oxygen species; (b) G2/M phase cell cycle arrest culminating ...
10 Ιουν 2021 · Benzoic Acid. The estrogen receptor α (ERα) is identified as an effective target for the treatment of ERα+ breast cancer; thus, discovery of novel selective estrogen receptor degraders (SERDs) are developed as an effective method to overcome the resistance of breast cancer. Herein, the hot-spot residues for prote ….
