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  1. 1 Νοε 2015 · The FRTA is one of the most popular aging theories and forms the basis for many antiaging products and strategies. Free radicals (FRs) are highly reactive molecules that react with organic molecules in a destructive way.

  2. Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.

  3. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establish mechanistic frameworks to understand the mechanobiological impacts of aging on disease progression and develop new strategies to halt and reverse the aging process.

  4. 20 Ιουλ 2022 · Having made substantial progress understanding molecules, cells, genes and pathways, aging biology research is now moving toward integration of these parts, attempting to understand how their ...

  5. This overview describes the historical background and modern versions of selected theories of the mechanisms of biological aging, including the mutation or genome instability theory, the free radical or oxidative stress theory, the mitochondrial theory, the error...

  6. Here, we discuss the evolutionary aspects of aging and a selection of theories founded on a variety of biological functions that have been shown to be involved in aging in multiple model organisms, ranging from the simple yeast, worms, flies, killifish, and rodents, to non-human primates and humans.

  7. 1 Νοε 2015 · Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases.