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28 Ιουλ 2023 · Hyperinsulinemic euglycemia (HIE) has emerged as a potent therapy for severe calcium channel blocker toxicity. Experimental models show that CCB toxicity shifts myocardial substrate preference to carbohydrates from free fatty acids; thus, cardiac substrate delivery is impaired.
Calcium channel blocker (CCB) toxicity is one of the most lethal prescription drug overdoses; therefore, understanding the emergent management of such cases is essential. Overdoses of...
9 Αυγ 2024 · Calcium channel blockers (CCBs) are used in the treatment of hypertension, angina pectoris, cardiac arrhythmias, and other disorders. These medications are available in both immediate-release and extended-release preparations; the latter are in wide clinical use .
12 Απρ 2021 · An Overview of Hyperinsulinemic-Euglycemic Therapy in Calcium Channel Blocker and β-blocker Overdose. Pharmacotherapy. 2018 Nov;38(11):1130-1142. doi: 10.1002/phar.2177 ; 30598720 Ahmed S, Barnes S. Hemodynamic improvement using methylene
3 Νοε 2020 · Severe calcium channel blocker toxicity is highly lethal, as a result of cardiovascular collapse; Good outcomes can be achieved through aggressive treatment and provision of circulatory support; MECHANISM OF TOXICITY. Verapamil and diltiazem are the most lethal calcium-channel blockers in overdose:
Management of cardiovascular instability resulting from calcium channel antagonist (CCB) or beta‐adrenergic receptor antagonist (BB) poisoning follows similar principles. Significant myocardial depression, bradycardia and hypotension result in both cases. CCBs can also produce vasodilatory shock.
The treatment for calcium channel blocker poisoning is supported by low-quality evidence drawn from a heterogeneous and heavily biased literature. High-dose insulin and extracorporeal life support were the interventions supported by the strongest evidence, although the evidence is of low quality.
