Αποτελέσματα Αναζήτησης
26 Ιουν 2018 · Methods. We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma, confirmed on histopathological testing, with measurable disease (contrast-enhancing...
24 Ιουν 2021 · The target is a brain tumor known as a malignant glioblastoma, which is aggressive and often fatal. Branded as LUMINOS-101, the therapy combines a viral immunotherapy based on the polio vaccine with an immunotherapy drug shown to be effective in other types of cancers.
25 Ιουν 2018 · The therapy includes a genetically modified form of the poliovirus vaccine, which is infused directly into the brain tumor via a surgically implanted catheter. Developed by Gromeier in his lab at Duke, the modified virus preferentially zeroes in on tumor cells, igniting a targeted immune response.
8 Μαρ 2024 · In a recent study published in Advanced Science, they showed that their vaccine (called the rWTC-MBTA vaccine) could extend survival and prevent tumor recurrence in mouse models. Eventually, they hope this vaccine could supplement conventional treatments to improve care for people with glioblastoma.
26 Ιουν 2018 · The therapy involves infusing the poliovirus vaccine directly into the brain tumor through a surgically implanted catheter. Developed by Duke’s Matthias Gromeier, MD, the genetically modified virus targets the tumor cells, creating an immune response.
27 Ιαν 2020 · A new clinical trial is looking into validating whether a modified version of the virus that causes polio can impact the survival rates of people with glioblastoma (GBM), a deadly cancer of the brain.
30 Ιαν 2020 · DURHAM, N.C. -- A modified form of poliovirus, pioneered at Duke Cancer Institute as a therapy for glioblastoma brain tumors, appears in laboratory studies to also have applicability for pediatric brain tumors when used as part of a cancer vaccine.
