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  1. 24 Σεπ 2024 · Gene therapy faces several technical challenges such as difficulty in delivering the working gene to specific cells, getting the gene into enough cells at the right rate, unintended cell transfer, and regulating gene expression.

  2. 6 Οκτ 2024 · Challenges in gene therapy include treatment frequency and patient rejection. Treatment frequency varies based on the chosen method and often requires multiple administrations over several months. To address patient rejection, strategies like using non-viral vectors, ex vivo treatments, or immunosuppressant drugs can help mitigate immune ...

  3. 20 Φεβ 2024 · In what ways can gene-delivery vectors cause serious illness or death due to an unwelcome immune response? Discuss the ethical considerations and challenges in balancing the potential benefits and risks of gene therapy.

  4. 8 Νοε 2023 · In this article, we highlight success and ongoing challenges in three areas of high activity in gene therapy: inherited blood cell diseases by targeting hematopoietic stem cells, malignant...

  5. 9 Οκτ 2020 · Gene correction using CRISPR-Cas9 is an extension of gene therapy that has received considerable attention in recent years and boasts many possible uses beyond classical gene therapy...

  6. 17 Δεκ 2019 · 22 Citations. 1 Altmetric. Abstract. Gene therapy as a novel study in molecular medicine will have a significant impact on human health in the near future. In recent years, the scope of gene therapy has been developed and is now beginning to revolutionize therapeutic approaches.

  7. Thus, one of the main challenges of gene therapy is to deliver gene therapy drugs to working sites, but naked gene therapy drugs have the following disadvantages: (1) Easily degraded by RNase in serum; (2) Recognized by serum immunologically active factors and phagocytosed by mononuclear macrophages; (3) Interact with serum proteins; (4) Renal ...

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