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Acta2 CRISPRa kit - CRISPR gene activation of mouse actin, alpha 2, smooth muscle, aorta
1 Οκτ 2024 · CladeOScope co-evolved genes for ACTA2 gene. Complete information for ACTA2 gene (Protein Coding), Actin Alpha 2, Smooth Muscle, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium.
ACTA 2. Gene Therapy and Editing for Smooth Muscle Dysfunction Syndrome. Smooth Muscle Dysfunction Syndrome is a rare disease with less than 50 known cases worldwide. It is caused by a specific genetic mutation in the ACTA2 gene that affects smooth muscle cells.
Many mutations in the ACTA2 gene have been found to date in patients with familial thoracic aortic aneurysms (dilatations and tears of the largest vessel in the body). Only few of them, and primarily those that change the amino acid Arginine 179 (Arg179) are associated with a more extensive form of the disease that affects the whole body.
The hub genes of JUN, FOS, MYC and ACTA2, as well as the DEGs IL18 and CD274 that were associated with the immune response in GO terms may exert important functions in the molecular mechanisms of PABC. These genes may be used as new molecular targets in the treatment of this disease.
Target-specific CRISPR Plasmids for both gene knockout and activation are available. Please refer to the detailed product information in the tabs below; Gene knockdown or activation can be assayed using α-Actin Antibody (1A4): sc-32251
ACTA2 CRISPRa kit - CRISPR gene activation of human actin alpha 2, smooth muscle
