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17 Φεβ 2023 · CRISPR-mediated transcriptional activation (CRISPRa) is a powerful technology for inducing gene expression from endogenous loci with exciting applications in high throughput gain-of-function...
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15 Μαρ 2024 · Different activation domains are suited to specific genes and cell types. CRISPRa pooled screening has enabled diverse applications in drug discovery, providing new insight into cell responses and cell differentiation, and even an understanding of SARS-CoV-2 mechanisms during infection.
1 Δεκ 2021 · Several studies have established that pigmentation disorders occur in the case of functional c-Kit aberration in both humans and mice. Additionally, inactivating heterozygous mutations in the Kit gene are attributed to piebaldism, a rare autosomal disorder characterized by congenital patchy depigmentation of the skin.
15 Μαΐ 2018 · The dCas9-VP64-mediated gene activation strategy was further improved by a number of second-generation CRISPR-based gene activation platforms.
15 Μαΐ 2018 · The dCas9-VP64-mediated gene activation strategy was further improved by a number of second-generation CRISPR-based gene activation platforms.
Target-specific CRISPR Plasmids for both gene knockout and activation are available. Please refer to the detailed product information in the tabs below; Gene knockdown or activation can be assayed using α-Actin Antibody (1A4): sc-32251
10 Μαρ 2015 · Individuals with ACTA2 mutations present with both type A and type B aortic dissections at significantly younger ages than individuals enrolled in the International Registry of Acute Aortic Dissection (IRAD) study 22 and are likely to report a family history of thoracic aortic disease.
