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Summary: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis.
Mutations in the ACTA2 gene lead to abnormal production of alpha smooth muscle actin isotype 2, a protein that forms part of the scaffolding of the contractile (shrinking) system of smooth muscle cells.
3 Μαρ 2023 · ACTA2 expression is associated with survival and ICI response in gastric cancer patients. ACTA2 expression in cancer-associated fibroblasts, but not in other cellular compartments, appears to be associated with ICI response. Keywords: gastric cancer, precision oncology, immunotherapy, predictive biomarker. Go to:
31 Οκτ 2013 · Abstract. Purpose: Metastatic relapse of primary lung cancer leads to therapeutic resistance and unfavorable clinical prognosis; therefore, identification of key molecules associated with metastatic conversion has significant clinical implications.
1 Οκτ 2024 · ACTA2 (Actin Alpha 2, Smooth Muscle) is a Protein Coding gene. Diseases associated with ACTA2 include Smooth Muscle Dysfunction Syndrome and Aortic Aneurysm, Familial Thoracic 6 . Among its related pathways are Actin Nucleation by ARP-WASP Complex and Integrin Pathway .
1 Ιουν 2021 · Cancer. Neoplasia. Transformation. Migration. Cytoskeleton. Introduction. Actin is an important and prominent structural protein that is found in all cells of the body and has a role in multiple cellular functions such as division, migration, chromatin remodelling, and vesicle trafficking.
Expression of ACTA2 (ACTSA) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
