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Mechanism of action. Clopidogrel is activated via a 2 steps reaction to an active thiol-containing metabolite. 3 This active form is a platelet inhibitor that irreversibly binds to P2Y 12 ADP receptors on platelets. 9 ... Poor drug metabolizer, lower dose requirements, higher risk for drug-drug interactions: Details: Unlock the secrets to ...
10 Ιουλ 2023 · Explain the mechanism of action of clopidogrel. Review the indications for initiating therapy with clopidogrel. Describe the significant drug-drug interactions that might occur when prescribing clopidogrel.
Coprescribing of clopidogrel and other drugs is common. Available reviews have addressed the drug–drug interactions (DDIs) when clopidogrel is as an object drug, or focused on combination use of clopidogrel and a special class of drugs.
7 Μαρ 2013 · One of them is clopidogrel drug–drug interaction with CYP2C19 and CYP3A4 enzyme inhibitors. The main goal of this descriptive study was to assess the prevalence of cases of clopidogrel–drug interactions in the primary health care physicians' practices.
19 Μαρ 2015 · The mechanism of the DDIs with clopidogrel involves modulating CYP enzymes (eg, CYP2B6, CYP2C8, CYP2C19, and CYP3A4), paraoxonase-1, hepatic carboxylesterase 1, P-glycoprotein, and organic anion transporter family member 1B1.
1 Μαρ 2011 · Multidrug therapy increases the risk for drug–drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y 12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes.
2 Σεπ 2020 · While variability in clopidogrel-induced antiplatelet effects is known to affect clinical outcomes, with high platelet reactivity being associated with thrombotic complications among patients undergoing coronary stenting, most studies assessing the clinical implications of clopidogrel–drug interactions have not shown to significantly affect outc...
