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19 Δεκ 2018 · At present, commercialized high-concentration biologics, with protein concentrations between 150 and 200 mg/mL, are launched as lyophilized (freeze-dried) products, while liquid protein formulations are available with concentrations around 100 mg/mL.
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From: Lyophilization of High-Concentration Protein...
- Lyophilization of Pharmaceuticals and Biologicals
This volume addresses new analytical tools and applications...
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9 Ιουν 2021 · Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins...
19 Δεκ 2023 · Protein condensates, including coacervates and liquid crystals, are crucial for the assembly of biological fibres, including elastic fibres, amyloid fibrils, spider silk and the mussel byssus...
17 Φεβ 2021 · Liquid–liquid phase separation of proteins underpins the formation of membraneless compartments in living cells. Elucidating the molecular driving forces underlying protein phase...
4 Οκτ 2019 · During germline development in C. elegans, two P-granule proteins, ZNFX-1 and WAGO-4, become phase separated from the P granule to form an independent liquid phase. This newly-formed phase further assembles into tri-condensation with the P granule and Mutator foci in a phase–to–phase manner to spatiotemporally regulate epigenetic ...
Proteins undergoing liquid-liquid phase separation are being discovered at an increasing rate. Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins along with the n ….
16 Μαΐ 2023 · For example, the accepted method for evaluating the viscosity behavior of a liquid dosage form at high concentration involves formulating the protein at multiple concentrations and generating a viscosity curve using a cone and plate rheometer.
