Αποτελέσματα Αναζήτησης
Absence of moderate to severe COPD exacerbation criteria (shown below) Moderate COPD exacerbation (mild respiratory failure) Respiratory rate above 30/min during emergency department admission Use of accessory respiratory muscles Presence of cor pulmonale PaO 2 <60 mmHg, PaCO 2 >45 mmHg, pH: 7.25-7.35 in room air Oxygen requirement FiO 2 <40%
The external validity was assessed using up to four criteria: validity of the underlying COPD diagnosis; validity of the definition of acute exacerbation of COPD; characterisation of severity of acute exacerbation of COPD; and the duration of follow-up (treatment studies only).
The objective of this guideline is to improve the quality of care for patients with COPD by providing a framework for management and treatment of mild to moderate acute exacerbations, and to improve symptoms, quality of life, and lung function while reducing morbidity and mortality.
treatment of COPD exacerbations that are not answered by existing guidelines. For the following six questions, we employed a systematic review of the literature followed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop treatment recommendations.
Most patients who are hospitalized with an exacerbation of COPD should be treated with systemic corticosteroids, unless side-effects are limiting [I, A]. A dose of prednisone, 40 mg orally daily, for a 5-day course, is appropriate for most patients, and a dose taper is unnecessary ( Table 3 ) [I, A].
Many antibiotics have been found to be effective for the treatment of an acute exacerbation of COPD. A review of 19 randomised controlled trials (RCTs) found that macrolides, fluoroquinolones, and amoxicillin/clavulanate may be considered equivalent for the treatment of patients with an acute bacterial exacerbation of chronic bronchitis in ...
Guideline Scope and Purpose. The purpose of this guideline is to provide primary care– relevant recommendations for the management of acute exacerbations of chronic obstructive pulmonary...
