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Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids from acetyl‐CoA subunits that are produced from a number of different pathways within the cell, most commonly carbohydrate catabolism.
- De novo lipogenesis in humans: metabolic and regulatory aspects
The enzymatic pathway for converting dietary carbohydrate...
- De novo lipogenesis in humans: metabolic and regulatory aspects
The enzymatic pathway for converting dietary carbohydrate (CHO) into fat, or de novo lipogenesis (DNL), is present in humans, whereas the capacity to convert fats into CHO does not exist....
De novo lipogenesis (DNL) is a complex and highly regulated metabolic pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are then esterified to storage triacylglycerols (TGs). These TGs could later provide energy via β-oxidation.
Download scientific diagram | The process of de novo lipogenesis (DNL) in humans, where palmitic acid is the major product, which may be further elongated or desaturated to form other fatty...
The enzymatic pathway for converting dietary carbohydrate (CHO) into fat, or de novo lipogenesis (DNL), is present in humans, whereas the capacity to convert fats into CHO does not exist. Here, the quantitative importance of DNL in humans is reviewed, focusing on the response to increased intake of ….
1 Δεκ 2020 · De novo lipogenesis (DNL) is the mechanism by which cells condense acyl units to make fatty acids (FAs), which are then diverted to lipid droplets for storage as triacylglycerols (TAGs) and later oxidation, incorporated into structural lipids, or used for post-translational modifications.
One of the major metabolic functions of the liver is to carry out de novo lipogenesis, which is the metabolic pathway that allows the conversion of excess carbohydrates into fatty acids. The process of de novo lipogenesis is covered in depth within this volume.
