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25 Οκτ 2021 · A positive impact from MMN supplementation during pregnancy for iron and folic acid is supported for several birth outcomes (decreased maternal anemia at term; reduction in low birth-weight babies; possible reduction in small-for-gestation age babies and reduced preterm birth).
7 Ιουν 2022 · Guidelines recommend 0.4 mg of folic acid per day in the periconceptional period, and certain guidelines recommend high doses (4-5 mg/day) in women at higher risk for neural tube defects such as those with diabetes, body mass index ≥30, or taking antiepileptic medications or other folate antagonists
Serum folate levels of 28–30 nmol/L (red blood cell folate level >907 nmol/L) have been extensively evaluated in pregnant populations, and there is clear evidence that this maternal red blood cell folate level protects against folic acid–related NTDs in the fetus. 10
1 Μαΐ 2024 · Folic acid supplementation is recommended for all females capable of becoming pregnant, particularly those planning to conceive, because, in addition to its other physiologic functions, periconceptional use decreases the occurrence and recurrence of fetal neural tube defects (NTDs).
This paper reviews the advantages and disadvantages of folate supplementation with folic acid versus 5-MTHF, with a focus on maternal and fetal health. Keywords: Hyperhomocysteinemia; Methyltetrahydrofolate reductase; Neural tube defect; Placenta; Pre-eclampsia; Vitamin B9.
16 Νοε 2020 · For prevention: a folate-rich diet, and folic acid and vitamin B 12 supplementation, with dosage depending on risk level. For screening: second-trimester anatomical sonography; first-trimester sonographic screening; maternal serum alpha fetoprotein; prenatal magnetic resonance imaging.
5 Μαρ 2020 · New regulations require folate to be declared as micrograms of dietary folate equivalents (DFE) on product labels, whereas intake recommendations for reducing the risk of neural tube defects (NTDs) and the Tolerable Upper Intake Level are expressed as micrograms of folic acid.
