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4 Δεκ 2020 · Ferritin <30 μg/L in the presence of TSAT <45% is indicative of absolute low iron stores (black). Most patients with CICs in association with true ID are found to have TSAT<20% and ferritin <200 μg/L (red).
Red blood cells tend to be microcytic and hypochromic, and iron stores are low, as shown by low serum ferritin and low serum iron levels with high serum total iron-binding capacity. Once the diagnosis is made, occult blood loss should be suspected until proven otherwise. Treatment involves iron replacement and treatment of the cause of blood loss.
6 Δεκ 2019 · Serum ferritin is the most reliable initial test for diagnosing absolute ID. 15 Ferritin is an intracellular iron storage protein that correlates with the body’s iron stores in the absence of inflammation.
Iron studies diagnostic for iron deficiency anemia consist of a low hemoglobin (<7.7 mmol/l in men and 7.4 mmol/l in women), a low serum iron (<7.1 µg/l), a low serum ferritin (storage form of iron) (<30 ng/l), a low transferrin saturation (<15%), and a high total iron-binding capacity (>13.1 µmol/l) [Bermejo and Garcia-Lopez, 2009; Clark, 2009].
10 Σεπ 2024 · The diagnosis of iron deficiency (low iron stores, as measured by iron studies or other testing) is a major public health goal and an important aspect of the care of many adults. This topic will review the causes of iron deficiency in adults and an approach to the diagnostic evaluation.
15 Ιουλ 2024 · Transferrin saturation (e.g., less than 15% in adult and less than 7% in pediatric subjects) helps define low plasma iron availability to tissues in both absolute and functional ID in adult subjects. Soluble transferrin receptor (sTfR) is an index of tissue iron needs and of erythropoietic activity.
9 Ιαν 2023 · The most commonly used threshold values for the diagnosis of ID are TSAT of < 20% and serum ferritin of < 100–300 µg/L. Noteworthy, both TSAT and particularly ferritin are frequently applied, but both may vary due to inflammatory conditions.
