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The dose–response relationship is a central concept in many biological disciplines, but especially in pharmacology, toxicology and risk assessment. Despite its centrality in the biological sciences, the origins of dose–response concepts and models remain underexplored and underappreciated.
3 Ιουν 2019 · Effective psychopharmacology is patient-specific, dose-sensitive, and time-dependent.
Optimal doses of psychotherapy in routine settings range between 4 and 26 sessions (4-6 for low intensity guided self-help) and vary according to setting, clinical population and outcome measures. Weekly therapy appears to accelerate the rate of improvement compared to less frequent schedules.
1 Αυγ 2022 · Abstract. The use of low doses of psychedelic substances (microdosing) is attracting increasing interest. This systematic review summarises all empirical microdosing research to date, including a set of infrequently cited studies that took place prior to prohibition.
6 Ιουν 2019 · The review reveals that dose delivered and dose received are conceptually distinct and may achieve health effects through separate pathways, encouraging researchers to measure dose in multiple ways and to use complex and complicated logic models to understand how change takes place
Assuming that toxicity is minimized or nonexistent in a behavioral intervention, an optimal dose can be defined as either the maximally efficacious dose that is not conditional on patient adherence (intended dose) or the maximally effective (actual or observed) dose that is conditional on adherence.
11 Μαΐ 2006 · To date, few studies have been published on the dose-response relationship, but there is general consensus that between 13 and 18 sessions of therapy are required for 50% of patients to improve. Reviewing the clinical trials literature reveals that in carefully controlled and implemented treatments, between 57.6% and 67.2% of patients improve ...
