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Five weeks of nightly administration of DXP 3 mg and 6 mg to adults with chronic primary insomnia resulted in significant and sustained improvements in sleep maintenance and early morning awakenings (with the exception of SE in the final quarter of the night on N29 for 3 mg [P = 0.0691]).
- Doxepin for insomnia: a systematic review of randomized ... - PubMed
Doxepin, a sedating tricyclic drug, at 3 mg and 6 mg doses...
- Doxepin for insomnia: a systematic review of randomized ... - PubMed
20 Απρ 2024 · A large, randomized, placebo-controlled trial has confirmed the sleep latency effects of doxepin 6 mg in a phase advance model of healthy adults. The antihistaminic effects of doxepin 3 mg may also lead to sleep latency benefits in adults with insomnia symptoms.
1 Νοε 2007 · The doxepin 6 mg dose significantly reduced subjective latency to sleep onset. All three doxepin doses had a safety profile comparable to placebo. There were no statistically significant differences in next-day residual sedation, and sleep architecture was generally clinically preserved.
Doxepin, a sedating tricyclic drug, at 3 mg and 6 mg doses was recently approved by the U.S. food and drug administration (FDA) for the treatment of insomnia. The objective of this systematic review was to obtain a precise summary of the efficacy and safety of doxepin as a hypnotic.
1 Φεβ 2015 · Study 2 showed that on night 1 compared to placebo, doxepin 3 and 6 mg could significantly lengthen total sleep time (TST), shorten latency to persistent sleep (LPS) and wake-time after sleep onset (WASO), and improve sleep efficiency (SE) in the last quarter of the night.
In this 2-night study of elderly adults with primary insomnia, doxepin doses of 1 mg, 3 mg, and 6 mg were well tolerated and produced significant improvement in objective and subjective sleep maintenance and duration endpoints that persisted into the final hour of the night.
1 Φεβ 2015 · We concluded that low-dose doxepin for 1–2 nights appeared to be safe and effective in improving sleep. However, a clear conclusion on its short-term benefits and risks as well as withdrawal effects was not possible due to the small number of studies.
