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1 Δεκ 2011 · In this review we summarize data on biological effects of the three most commonly used lipophilic drug vehicles dimethylsulfoxide (DMSO), propylene glycol (PG) and ethanol. Besides in...
Solvent is the substance that is capable of dissolving solute and usually constitutes the greater proportion in a solution. true solution is a homogenous mixture of two or more components in which solute molecules are dispersed as small molecules or ions throughout the solvent.
on drug product safety. For chemical entities, impurities can include organic impurities (including potential genotoxic impurities), inorganic impurities , for example metal residues, and residual solvents (see ICH Q6A, Q3A, and Q3C). For biotechnological/biological products, impurities may be process-related or product-related (see ICH Q6B).
28 Ιαν 2021 · [Show full abstract] Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown and dissolution of...
In pharmacology, one speaks of pharmaco-dynamic effects to indicate what a drug does to the body, and pharmacokinetic effects to indi-cate what the body does to a drug, two aspects of the behavior of drugs that are strongly inter-dependent.
The purpose of a buffer in a biological system is to maintain intracellular and extracellular pH within a very narrow range and resist changes in pH in the presence of internal and external influences.
In this chapter, we mainly discuss dilution of liquid solutions, but the same concept can be applied for homogeneous solid and semisolid mixtures. Dilution of a drug solution can be accomplished by changing the volume of the nal solution while.
