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This study confirmed the effectiveness of combined citicoline treatment in patients with mixed dementia and Alzheimer's disease, with a significant effect on the increase of MMSE score over time. The treated group also showed a significant reduction in the Geriatric Depression Scale and a significan ….
- PubMed
Background: Citicoline is a drug used both in degenerative...
- PubMed
Results: Six studies were found to match the combination treatment of citicoline with AcheIs and/or memantine. The CITIRIVAD and CITICHOLINAGE studies were the first to report the potential benefits of adding citicoline to acetylcholinesterase inhibitors (AchEIs).
Its aim was to assess the efficacy of CDP-choline 1,000 mg administered intramuscularly once a day in patients suffering from mild-to-moderate vascular dementia. The study showed significant differences in favor of active treatment over the placebo on delayed recall and memory index.
Background: Citicoline is a drug used both in degenerative and in vascular cognitive decline; memantine is a drug used for the treatment of mild to moderate Alzheimer's disease (AD). Our hypothesis is that their combined use could have enhanced action in patients having AD and mixed dementia (MD).
21 Δεκ 2021 · Piamonte et al [711] in their review concluded that that citicoline used in adjunct with acetylcholinesterase inhibitors in the treatment of Alzheimer's disease was well-tolerated and...
1 Ιουλ 2014 · A recent study by Alvarez-Sabin et al. showed that citicoline treatment for 12 months in patients with first-ever ischemic stroke is safe and probably effective in improving poststroke cognitive decline.
6 Ιουν 2020 · Limited evidence from pooled data of two observational studies suggests that CC used in adjunct with AChEIs in the treatment of AD was well-tolerated and showed improvement in cognition, mood, and behavioral symptoms compared to treating with AChEIs alone.
