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16 Νοε 2020 · This study recommends citicoline as a possible protective mediator with therapeutic and antioxidant capability against acute liver failure and HE. Therefore, this drug might be a candidate for attenuating HE adverse effects in clinical settings.
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Evaluation of brain tissue ROS formation (A), total...
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The most frequently presented explanation for the neuroprotective effects of citicoline on the brain is based on the assumption that it is a prodrug which, following injection or ingestion, is sequentially hydrolysed and dephosphorylated, finally, to cytidine (or uridine in humans) and choline.
27 Δεκ 2022 · This review is focused on the main indications of the drug, as acute stroke and its sequelae, including the cognitive impairment, and traumatic brain injury and its sequelae.
2 Σεπ 2024 · The impact of citicoline on cyclooxygenase-2 (COX-2), an enzyme that is involved in inflammation and cancer, is not well understood. COX-2 is a key target for anti-inflammatory and anti-cancer drugs, but it also has some beneficial roles in the body.
16 Νοε 2020 · This study recommends citicoline as a possible protective mediator with therapeutic and antioxidant capability against acute liver failure and HE. Therefore, this drug might be a candidate for attenuating HE adverse effects in clinical settings.
12 Νοε 2020 · Results: The result of the study revealed that plasma and brain ammonia and the liver injury markers increased, and locomotor activity impaired in the APAP-treated animals.
Citicoline is considered a dietetic source of choline and cytidine. Cytidine does not have any health claim authorized either, but there are claims authorized for choline, concerning its contribution to normal lipid metabolism, maintenance of normal liver function, and normal homocysteine metabolism.
