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Citicoline (cytidine-5′-diphosphocholine, CDP-choline) is an example of such a drug, as it already has been established as a promising therapy to treat stroke and brain injury (2). The scope of citicoline’s therapeutic potential extends beyond its ability to be neuroprotective.
- Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved ...
The most frequently presented explanation for the...
- Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved ...
16 Δεκ 2010 · Citicoline safety was excellent; only 37 side effects were observed in 31 patients (0.73%). The most frequent were headache (n=3), gastrointestinal symptoms (n=5), systemic bleeding (n=4), and stroke-related complications (n=8).
The most frequently presented explanation for the neuroprotective effects of citicoline on the brain is based on the assumption that it is a prodrug which, following injection or ingestion, is sequentially hydrolysed and dephosphorylated, finally, to cytidine (or uridine in humans) and choline.
28 Ιουλ 2012 · The primary objective of this study was to assess the effects of citicoline compared with placebo on the recovery of patients with moderate-to-severe acute ischaemic stroke at 3 months, after having received 2000 mg daily for 6 weeks.
6 Ιουν 2020 · The adverse effects reported in both studies were few and self-limiting, suggesting an encouraging safety profile for combined treatment of AChEIs + CC. Documentation and reporting of such adverse effects, however, may be limited by recall or reporting bias, leading to the possible underreporting of these events.
2 Σεπ 2024 · Current clinical investigations into the impact of citicoline on acute ICH are limited and ongoing. One noteworthy study in progress is the CO-OPERA trial (Citicoline Oral Plus Endovascular Recanalization for Acute Ischemic Stroke).
Based on the results obtained in these clinical studies, it is possible to conclude that citicoline is able to accelerate the recovery of consciousness and to improve the outcome of this kind of patient, with an excellent safety profile. Thus, citicoline could have a potential role in the management of TBI.
