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24 Σεπ 2021 · The Kleihauer-Betke test (KB) is a blood test used during pregnancy to quantify the amount of fetal blood found in the maternal circulation. Most commonly, the KB test is used to assess the severity of fetomaternal hemorrhage (FMH) so pregnant Rh-negative individuals may receive an appropriate dose of prophylactic anti-Rh immune globulin.
14 Σεπ 2011 · This two-minute alkali denaturation technique has been considered to give accurate and clinically useful results in the 0–40% range of Hb F but to underestimate the amount of Hb F at higher levels; although in clinical situations, this is not a problem.
8 Αυγ 2022 · Fetomaternal hemorrhage (FMH) occurs when there is a break in the placental barrier, allowing blood from the fetal circulation to enter the maternal circulation. This disruption in the placental barrier may occur for many reasons, including intrauterine fetal demise and trauma.
3 Μαΐ 2021 · Less normal haemoglobin results in less oxygen delivery to fetal tissues. A fetus born to two parents with alpha-thalassaemia trait has a one in four chance of having alpha-thalassaemia major.
29 Ιαν 2024 · The Kleihauer–Betke (KB) test allows the detection of fetal red blood cells (containing fetal hemoglobin, HbF) in the maternal blood to identify and quantify potential fetal-maternal hemorrhages. In certain cases, detecting fetal red blood cells with conventional staining is difficult.
5 Σεπ 2024 · Fetal hemoglobin (Hb F; alpha2gamma2) is the major hemoglobin in fetal red blood cells (RBCs) during gestation and constitutes 60 to 80 percent of total hemoglobin in the full-term newborn. By approximately 6 to 12 months of age, Hb F is almost completely replaced by adult hemoglobin (Hb A; alpha2beta2).
Fetal hemoglobin (HbF) is the main hemoglobin fraction during fetal life and accounts for approximately 80% of total hemoglobin at birth. After birth, HbF synthesis gradually decreases and is replaced by HbA; from the second year of life, HbF levels are usually below 1%.
