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24 Σεπ 2021 · The Kleihauer-Betke test (KB) is a blood test used during pregnancy to quantify the amount of fetal blood found in the maternal circulation. Most commonly, the KB test is used to assess the severity of fetomaternal hemorrhage (FMH) so pregnant Rh-negative individuals may receive an appropriate dose of prophylactic anti-Rh immune globulin.
14 Σεπ 2011 · This two-minute alkali denaturation technique has been considered to give accurate and clinically useful results in the 0–40% range of Hb F but to underestimate the amount of Hb F at higher levels; although in clinical situations, this is not a problem.
3 Μαΐ 2021 · Less normal haemoglobin results in less oxygen delivery to fetal tissues. A fetus born to two parents with alpha-thalassaemia trait has a one in four chance of having alpha-thalassaemia major.
8 Αυγ 2022 · Fetomaternal hemorrhage (FMH) occurs when there is a break in the placental barrier, allowing blood from the fetal circulation to enter the maternal circulation. This disruption in the placental barrier may occur for many reasons, including intrauterine fetal demise and trauma.
29 Ιαν 2024 · The Kleihauer–Betke (KB) test allows the detection of fetal red blood cells (containing fetal hemoglobin, HbF) in the maternal blood to identify and quantify potential fetal-maternal hemorrhages. In certain cases, detecting fetal red blood cells with conventional staining is difficult.
29 Απρ 2013 · We report two novel mutations found on the promoter of the Aγ gene and summarize all common and rare determinants associated with hereditary persistence of fetal hemoglobin (HPFH) described thus far.
Fetal hemoglobin, or foetal haemoglobin (also hemoglobin F, HbF, or α 2 γ 2) is the main oxygen carrier protein in the human fetus. Hemoglobin F is found in fetal red blood cells, and is involved in transporting oxygen from the mother's bloodstream to organs and tissues in the fetus.