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In light of increased use of propylene glycol in foods, cosmetics, and drugs, and as a substitute for ethylene glycol, additional inhalation, oral, and dermal kinetic studies would be helpful in predicting human kinetic response to propylene glycol exposure.
Ethylene glycol is a potent cause of acute toxicity in humans. In contrast, propylene glycol is a “generally recognized as safe” additive for foods and medications. Most reported cases of propylene glycol toxicity have resulted from propylene glycol used as a diluent for intravenous administration of benzodiazepines (Kraut and Kurtz 2008).
2 Μαρ 2018 · The estimated exposure to propylene glycol through foods in the US is 15 mg per pound (34 mg/kg) per day (9). In comparison, one person who developed symptoms of toxicity was receiving 213...
The most important routes of exposure to propylene glycol for members of the general population are ingestion and dermal contact with products containing this compound. The general public also may be exposed to small amounts of propylene glycol released from newly installed carpet with polyvinyl backing.
Ethylene glycol and propylene glycol are clear liquids used in antifreeze and deicing solutions. Exposure to large amounts of ethylene glycol can damage the kidneys, heart, and nervous system. Propylene glycol is generally regarded as safe for use in food.
The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties.
Symptoms seen in humans from short-term and long-term exposure were similar. TCE can harm the central nervous system and damage the kidneys, liver, immune system, male reproductive system, and the developing embryo or fetus.
