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20 Οκτ 2020 · The free-radical theory of aging was formally proposed by Denham Harman in 1956 and postulates that the inborn process of aging is caused by cumulative oxidative damage to cells by free radicals produced during aerobic respiration.
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
The free radical theory as proposed by Harmon in the mid-1950s was the catalyst for many studies into aspects of free radical metabolism and mitochondrial function that have shown links between oxidative stress, brain aging, and neurodegenerative disease.
1 Οκτ 2018 · Significance: The two foremost concepts of aging are the mechanistic free radical theory (FRT) of how we age and the evolutionary antagonistic pleiotropy theory (APT) of why we age. Both date from the late 1950s.
4 Σεπ 2022 · Free radical theory, which links aging to the DNA damage of "free radicals" acting on cells; Protein cross-linking theory, based on chemical changes interacting with each other in the body; Somatic DNA damage theory, which holds that your genetic makeup controls aging until death
The free radical theory of aging, one of the nine suggested hallmarks of aging (López-Otín et al., 2016), implicates the gradual accumulation of oxidative cellular damage as a fundamental driver of cellular aging (Harman, 1956; Miquel et al., 1980).
The free radical theory of aging arose in 1954 from a consideration of aging phenomenon from the premise that a single common process, modifiable by genetic and environmental factors, was responsible for the aging and death of all living things.
