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5 Ιουλ 2024 · The coagulase enzyme, produced by Staphylococcus aureus, is a protein that plays a significant role in the bacterium’s interaction with its host. This enzyme exists in two forms: bound coagulase, also known as “clumping factor,” and free coagulase.
Coagulase is an enzyme which causes the clotting of blood plasma. Coagulases clot blood plasma in a similar mechanism to normal clothing. Although the activities of coagulase may not be required for pathogenicity but could indicate that S. aureus is capable of being pathogenic.
Coagulase. Coagulase is not an enzyme. It is an extracellular protein which binds to prothrombin in the host to form a complex called staphylothrombin. The protease activity characteristic of thrombin is activated in the complex, resulting in the conversion of fibrinogen to fibrin.
One of the hallmarks of S. aureus is its ability to coagulate blood , allowing for clinical differentiation of S. aureus from coagulase-negative Staphylococci (CoNS) such as S. epidermidis . S. aureus secretes two soluble coagulases that interact with prothrombin to catalyze conversion of fibrinogen to fibrin ( McAdow et al., 2012b ).
S. aureus uses coagulase to form a fibrin coat from fibrinogen present in the bloodstream. This helps the bacteria evade detection and phagocytosis by the immune system. Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin.
Coagulase is the enzyme which catalyses the conversion of fibrinogen to fibrin. It is most closely associated with pathogenicity, having previously been used in the microbiology laboratory to separate pathogens from non-pathogens.
Abstract. Clinical isolates of Staphylococcus aureus secrete coagulases, polypeptides that bind to and activate prothrombin, thereby converting fibrinogen to fibrin and promoting the clotting of plasma or blood.
