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Cells are coated with C3b during opsonization, which provides a binding surface for secreted Efb. Fibrinogen then interacts with the bound Efb to create a shield around the cell, masking complement factors and protecting the cell from phagocytosis (Ko et al., 2013).
Coagulase is the enzyme which catalyses the conversion of fibrinogen to fibrin. It is most closely associated with pathogenicity, having previously been used in the microbiology laboratory to separate pathogens from non-pathogens.
Coagulase is an enzyme which causes the clotting of blood plasma. Coagulases clot blood plasma in a similar mechanism to normal clothing. Although the activities of coagulase may not be required for pathogenicity but could indicate that S. aureus is capable of being pathogenic.
5 Αυγ 2010 · Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin, thereby converting fibrinogen to fibrin and promoting clotting of plasma or blood. Another secreted coagulase, designated von-Willebrand factor binding protein (vWbp), catalyzes a similar reaction.
Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates.
5 Ιουλ 2024 · Published Jul 5, 2024. Staphylococcus aureus is a prominent bacterial pathogen responsible for various infections, ranging from minor skin conditions to severe systemic diseases. Among its virulence factors, the coagulase enzyme stands out due to its unique ability to manipulate host clotting mechanisms.
1 Ιαν 2018 · Staphylococcal coagulases (Coa, vWbp) are secretory proteins that cause blood clotting through the activation of prothrombin. Based on their ability to clot plasma staphylococci, they may be divided into coagulase-positive or coagulase-negative ones.
