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Furosemide is prepared from 4,6-dichlorobenzoic acid-3-sulfonylchloride via a multistep synthesis involving the sequential addition of ammonia and 6-furfurylamine (Sturm et al., 1962). It is synthesized in Brazil, Bulgaria, China, Hungary, Israel, Italy, Poland, Switzerland and the USA (Chemical Information Services, 1989–90).
The volume of distribution following intravenous administration of 40 mg furosemide were 0.181 L/kg in healthy subjects and 0.140 L/kg in patients with heart failure. 6 Protein binding Plasma concentrations ranging from 1 to 400 mcg/mL are about 91-99% bound in healthy individuals.
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Furosemide | C12H11ClN2O5S | CID 3440 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Medscape - Hypertension-specific dosing for Lasix, Furoscix (furosemide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
6 Απρ 2024 · Furosemide, a potent loop diuretic widely used for managing fluid overload conditions like congestive heart failure, liver cirrhosis, and renal dysfunction, is thoroughly reviewed in this paper.
