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Furosemide has a steep dose-effect curve, and therapeutic doses range from 40 to 200 mg daily in adults (Weiner & Mudge, 1985). Treatment of oedema is usually started with an initial oral dose of 40 mg daily; in severe cases, a gradual increase up to 600 mg daily may be required.
6 Απρ 2024 · Furosemide, a potent loop diuretic widely used for managing fluid overload conditions like congestive heart failure, liver cirrhosis, and renal dysfunction, is thoroughly reviewed in this paper.
8 Μαΐ 2023 · Furosemide is a loop diuretic that has been in use for decades. The Food and Drug Administration (FDA) has approved furosemide to treat conditions with volume overload and edema secondary to congestive heart failure exacerbation, liver failure, or renal failure, including the nephrotic syndrome.
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The volume of distribution following intravenous administration of 40 mg furosemide were 0.181 L/kg in healthy subjects and 0.140 L/kg in patients with heart failure. 6 Protein binding Plasma concentrations ranging from 1 to 400 mcg/mL are about 91-99% bound in healthy individuals.
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