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Pocket Guide for asthma management and prevention for adults and children older than 5 years (updated 2020). Summary for primary health care providers, to be used in conjunction with the main GINA report. Difficult-to-treat and severe asthma in adolescent and adult patients. Diagnosis and Management.
Administer XOLAIR 75 mg to 600 mg by subcutaneous injection every 2 or 4 weeks • Determine dose (mg) and dosing frequency by serum total IgE level (IU/mL) measured before the start of treatment, and by body weight (kg) • Adjust doses for significant changes in body weight during treatment
4 Δεκ 2023 · Dosing and adverse effects – The initial dose of inhaled glucocorticoids for mild persistent asthma should be in the low-dose range . The usual starting dose and the different types of inhaled glucocorticoids are shown in the low-dose column in the table .
We propose a reclassification of ICS doses based on the “standard daily dose,” which is defined as 200–250 μg of FP or equivalent, representing the dose at which about 80–90% of the maximum achievable therapeutic benefit of ICS is obtained in adult asthma across the spectrum of severity.
The intensity of treatment depends on the severity of symptoms: up to 3 treatments at 20-minute intervals as needed. In steps 3 and 4, the preferred option includes the use of ICS-formoterol 1 to 2 pufs as needed up to a maximum total daily maintenance and rescue dose of 12 pufs (54 mcg). .
Use of aerosolized forms with a spacer or holding chamber facilitates deposition of the drug in the airways rather than the pharynx; patients are advised to wash and dry their spacers after each use to prevent bacterial contamination.
Dosages of 2 mg (10 puffs) of inhaled fluticasone daily, 800 µg (4 puffs) of budesonide, and 6 mg/h (24 puffs) of flunisolide were used for acute asthma with good results. 18,47,48 In adults, this strategy was as effective as 40 mg of prednisone in resolving an acute exacerbation of asthma.
