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23 Σεπ 2021 · Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that...
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Genetic causes of obesity can be broadly classified into: Monogenic causes: those caused by a single gene mutation, primarily located in the leptin- melanocortin pathway. Syndromic obesity: severe obesity associated with other phenotypes such as neurodevelopmental abnormalities, and other organ/system malformations.
14 Σεπ 2017 · In supporting a causal association of obesity with diabetes, coronary heart disease, specific cancers, and other conditions, these analyses have clinical relevance in identifying which outcomes could be preventable through weight loss interventions. This is the first in a Seriesof three papers about obesity.
7 Ιουλ 2017 · Obesity is a global health problem mainly attributed to lifestyle changes such as diet, low physical activity or socioeconomics factors. However, several evidences consistently showed that genetics contributes significantly to the weight-gain susceptibility.
11 Οκτ 2023 · Taken together, enormous progress has been made in understanding the genetic architecture of obesity and the correlation of epigenetic marks with obesity and related traits. This review aims at highlighting current research and its challenges in genetics and epigenetics of obesity.
There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status but that is lower among normal weight individuals (about 30%) and substantially higher in the subpopulation of individuals with obesity and severe obesity (about 60%-80%).
4 Ιαν 2024 · The most frequent cause are mutations in the genes of the leptin/melanocortin axis involved in food intake regulation. Syndromic obesity is defined by severe obesity before the age of 6, accompanied by additional features like intellectual disability and organ-specific diseases.
