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Dose MUST be individualised according to renal function and weight - the gentamicin dosing calculator on the GAPP antimicrobial app should be used to calculate the dose. Dose should not normally exceed 400mg for once daily dosing regimen.
An antimicrobial app and/or online calculator is available and should be used to calculate the initial gentamicin dose. STEP 1: . Calculate, prescribe and administer the first dose. To reduce the risk of mortality, commence gentamicin administration within 1 hour of recognising sepsis.
Gentamicin Calculator in Adults. This Gentamicin Calculator can be used for all Gentamicin Prescribing except for Infective Endocarditis or Surgical Prophylaxis at the Royal Bournemouth Hospital site. See the Adult Antimicrobial Microguide on this page for details.
Calculate the initial dose by multiplying the patient’s actual body weight (or corrected dosing weight if the patient is obese) by 2.5 (i.e. 2.5 mg/kg ) to a maximum of 180 mg. Alternatively a SINGLE dose of 7 mg/kg may be considered (do not repeat this dose).
Record the exact time of all gentamicin doses and samples on the recording chart. • Plot the concentration measurement on the graph and reassess the dose / dosing interval as indicated. • If the concentration is unexpectedly high, or if renal function alters, daily sampling may be necessary.
Step 1: Calculate, prescribe and administer the first dose. To reduce the risk of mortality, commence gentamicin administration within 1 hour of recognising sepsis. If creatinine is known – use the online Gentamicin calculator (preferred method) or the guidelines in Table 1 (below).
Calculating the first dose of gentamicin. If creatinine is known ‐ use the online gentamicin dose calculator. If creatinine is not known ‐ give 5mg/kg gentamicin (maximum 400 mg) or, if CKD 4 or 5, give 2∙5mg/kg (maximum 180mg) on advice of senior medical staff.
