Αποτελέσματα Αναζήτησης
27 Ιουλ 2018 · We probed multiple biochemical processes in humans with fatty liver using the enrichment and distribution of 13 C and 2 H in plasma TG-glycerol and glucose after oral administrations of [U-13 C 3]glycerol and 2 H 2 O. Subclinical hepatic steatosis was associated with enhanced and more rapid metabolism of [U-13 C 3]glycerol through pathways that ...
- Fig. 6B, C
Sources of glucose after [U-13 C 3]glycerol...
- Fig. 5A
It is a challenge to assess metabolic dysregulation in fatty...
- Energy Metabolism in the Liver
Alanine, lactate, and glycerol are delivered to the liver...
- Fig. 6B, C
21 Ιουλ 2017 · Impaired suppression of HGP is reproducibly associated with increased intrahepatic triglyceride (IHTG) content, which is a hallmark of non-alcoholic fatty liver disease (NAFLD).
17 Οκτ 2024 · This work found that glycerol kinase (GK) is upregulated in diet-induced and genetic mouse models of nonalcoholic fatty liver (NAFL). Fatty acids and cholesterol stimulate GK expression in hepatocyte...
1 Απρ 2012 · This review focuses on novel findings related to nuclear receptor signaling – including the vitamin D receptor and the liver receptor homolog 1 – in hepatic lipid and glucose uptake, storage and metabolism in the clinical context of NAFLD, liver regeneration, and cancer.
It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and cholesterol metabolism. However, over the last decades, a variety of pathological conditions highlighted the importance of metabolic functions within the diseased liver.
Alanine, lactate, and glycerol are delivered to the liver and used as precursors to synthesize glucose (gluconeogenesis). NEFAs are oxidized in hepatic mitochondria through fatty acid β oxidation and generate ketone bodies (ketogenesis).
The other product of adipose tissue lipolysis is Glycerol, which is converted into glycerol-3-phosphate (G3P) in the liver by Glycerol-3 kinase (G3K). The increased flux of glycerol to the liver increases gluconeogenic flux, leading to hyperglycemia [ 32 , 35 , 36 ] ( Figure 2 ).
