Αποτελέσματα Αναζήτησης
21 Ιαν 2022 · Since helminth infection is not an appropriate treatment direction due to the complex immunoregulation and safety concerns, one of the new therapies is to harness the immunoregulation induced by the identified helminth-derived molecules using immune indexes as a guide.
- Table 1
Omega-1: Schistosoma mansoni eggs: DCs→ Th2 cells: Th2...
- Open in a Separate Window
Figure 3. Open in a separate window. The pathogenesis of...
- Table 1
26 Αυγ 2016 · In the authors' opinion, helminth therapy can be approached from 3 broad perspectives: (1) use of viable ova/larvae, (2) administration of helminth-derived extracts or purified molecules, and (3) cellular immunotherapy with helminth extract/antigen-pulsed immune cells.
The aim of this systematic review was to investigate whether there is evidence to support the use of helminth therapy for the management of Crohn's disease and ulcerative colitis. Four databases (PubMed, Embase, Medline and the Cochrane Central Register of Control Trials) were searched for primary evidence in the form of clinical studies.
Several studies in animal models have demonstrate that intestinal helminth infections are able to inhibit the development of intestinal inflammation (reviewed in [14,15]) and the first clinical studies of helminth therapy in humans started some 10–15 years ago with the use of the pig whipworm Trichuris suis.
Because TH1-mediated immune responses characterize the inflammatory infiltrate of both Crohn's disease and ulcerative colitis, at least partially, helminthes may exert their anti-inflammatory effect through the induction of specific TH2 cytokines (47, 48).
Since helminth infection is not an appropriate treatment direction due to the complex immunoregulation and safety concerns, one of the new therapies is to harness the immunoregulation induced by the identified helminth-derived molecules using immune indexes as a guide.
14 Μαΐ 2020 · Studies of live helminth therapy in mice and larger animals have convincingly shown that helminths and their excretory/secretory products possess anti-inflammatory drug-like properties and represent an untapped pharmacopeia.
