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11 Νοε 2021 · Examination and differentiation of bone marrow (BM) cell morphologies are important cornerstones in the diagnosis of malignant and nonmalignant diseases affecting the hematopoietic system 1-5 Although a large number of sophisticated methods, including cytogenetics, immunophenotyping, and, increasingly, molecular genetics, are now available, cyto...
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Structure of the 21 morphological classes of BM cells used...
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Artificial intelligence (AI) and machine learning algorithms...
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UMAP embedding of extracted features. UMAP embedding of the...
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17 Αυγ 2023 · The morphological examination of bone marrow (BM) nucleated cells plays a crucial role in the diagnosis of various hematological diseases, including acute leukemia (AL), chronic leukemia...
30 Οκτ 2023 · Histological analysis of the bone marrow will reveal an abundance of progenitor cells and their derivatives at different stages of development. Typically, the progenitor cells are larger than their end products.
The interpretation of bone marrow aspiration and histology should provide quantitative information as well as a morphologic assessment of individual cells and cell lines. Most of the bone marrow abnormalities relate to the overall cellularity and/or presence of cell types.
Depending on need, the bone marrow microenvironment and growth factors influence pluripotent stem cells to differentiate into committed stem cells of either the myeloid or lymphoid series (multipotential stem cells), or the second stage of hematopoiesis.
The bone marrow is best described as a unique semisolid organ which exists in a fine balance and has a dynamic relationship with lymphoid tissues and the peripheral blood. The main function of the marrow is production of haematopoietic cells which develop from a small group of self-propagating stem cells.
1 Μαΐ 2023 · Introduction. Hematopoiesis is the process of creating a wide variety of blood and bone marrow cells, namely erythrocytes, platelets, granulocytes, lymphocytes, and monocytes. This process begins with multipotent hematopoietic stem cells (HSC) which have the capability of dividing into either a multipotent progenitor cell or to self-renew.
