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30 Οκτ 2023 · Histological analysis of the bone marrow will reveal an abundance of progenitor cells and their derivatives at different stages of development. Typically, the progenitor cells are larger than their end products.
The components involved in bone marrow histology are cortical and trabecular bone and stroma, vasculature, sinus wall layers, nerves, hematopoietic cells, and non-hematopoietic interstitial cells. Refer to Box 2, Box 3 for a checklist and list of histochemical stains used to assess bone marrow histologic specimens. Box 2.
Bone marrow is highly cellular. This makes identification of developing blood cells very difficult. The exception is the large megakaryocytes (#1, #2, and #3). Similar to blood, smears made from suspensions of bone marrow cells are preferable for the identification of other types of blood cells.
18 Νοε 2021 · Automated morphological analysis of bone marrow cells in microscopic images for diagnosis of leukemia: nucleus-plasma separation and cell classification using a hierarchical tree model of hematopoesis.
Depending on need, the bone marrow microenvironment and growth factors influence pluripotent stem cells to differentiate into committed stem cells of either the myeloid or lymphoid series (multipotential stem cells), or the second stage of hematopoiesis.
The bone marrow is best described as a unique semisolid organ which exists in a fine balance and has a dynamic relationship with lymphoid tissues and the peripheral blood. The main function of the marrow is production of haematopoietic cells which develop from a small group of self-propagating stem cells.
The cellular components. Stem cells: the bone marrow stem cells include the hematopoietic stem cell and the mesenchymal stem cell. The haematopoietic stem cells differentiate into various haematopoietic cell lines and the mesenchymal stem cells give rise to stromal cells. 5.
