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10 Φεβ 2017 · HIV (human immunodeficiency virus) is a virus that attacks the body’s immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). For information purposes...
An explanation of HIV Protease structure, the action of drugs on it, and the development of resistance.
17 Ιουλ 2011 · Animation of the HIV-1 Protease Reaction Mechanism. Created for CHEM 237 at the University of Waterloo.
5 Ιουλ 2024 · The major tests used as screening tests for diagnosing HIV are (1) HIV antigen-antibody laboratory-based tests, (2) HIV antigen-antibody point-of-care tests, (3) HIV antibody laboratory-based tests, and (4) HIV antibody point-of-care tests.
HIV-1 protease or PR is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS.
The function of HIV protease is to cleave the initial polyprotein into its functional constituents (Sussman et al., 2013). This enzyme is made up of a dimer of identical subunits that mimics the two-lobed monomeric structure of pepsin and other aspartate proteases.
Once administered, protease inhibitors work by binding and inhibiting the viral enzyme HIV protease, which plays a major role in maturation of newly replicated viruses. The result is the formation of immature viruses, which are unable to continue infecting host cells.
