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Insulin therapy is the mainstay of treatment for clinical DM. The guidelines provide rec-ommendations for each insulin formulation currently available for use in dogs and cats, the choice of which is generally based on efficacy and duration of effect in the respective species. Also discussed are non-insulin therapeutic medications
These charts show the curves you would expect to find in a diabetic dog and cat that have little or no clinical signs as well as 4 problem scenarios. Most of the examples below are plotted against over 24 hours but can be easily adapted to a 12-hour timeline. Note: Insulin given at time=0.
Doses of insulin are measured in units: 40 IU/ml insulin contains 40 International Units (IU) per millilitre (ml). Use Caninsulin with U-40 syringes only to avoid dosing errors when administering Caninsulin to dogs. Human insulin is formulated at a concentration of 100 IU / ml.
The glucose curve helps determine: Insulin effectiveness. Maximum and minimum blood glucose levels, which should ideally be between 5 and 14 mmol/l. Glucose nadir (lowest level) goal: 5-8 mmol/l. Duration of insulin effectiveness: Duration of effectiveness used to determine frequency of insulin injections.
CHART: Plot the blood glucose concentrations against time to create the blood glucose curve. Ideal nadir or lowest blood glucose level after insulin administration: 100-125 mg/dL. DOGS. 120-200 mg/dL. CATS. > >250 mg/dL mg/dL. DOGS CATS.
10 Μαΐ 2019 · Most dogs are well controlled on insulin at an average dose of 0.5 U/kg q 12 hr with a range of 0.2–1.0 U/kg.The duration of action is close to 12 hr in most dogs, and the amorphous component of the insulin helps to minimize postprandial hyperglycemia.
The recommended starting dose is 0.25–0.50 U/kg every 12 hours. In one study that included well controlled diabetic dogs, the mean dose of NPH insulin was 0.63 (range 0.40–0.97) U/kg every 12 hours. 3. NPH is a recombinant human insulin made by nonpathogenic bacteria; the strain used depends upon the name brand.
