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7 Μαΐ 2018 · The enigma of dual IgD and IgM expression has been tackled by several recent studies showing that IgD helps peripheral accumulation of physiologically autoreactive B cells through its functional unresponsiveness to self-antigens but prompt readiness against foreign antigens.
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Eur. J. Immunol. 2018. 48: 1101–1113 DOI:...
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IgD has antibody activity to specific antigens (34, 53, 60, 109, 110); individuals with high levels of IgD can produce specific IgD antibodies after antigenic challenge .
17 Οκτ 2018 · An analysis of IgD-secreting plasma cells from human tonsillar crypts revealed serum IgD antibodies specific for common small soluble antigens including food proteins.
Two mechanisms could be postulated for the role of IgD in the positive section of self-reactive B cell clones: (i) small differences in intensity and kinetics between IgM- and IgD-mediated signals are sufficient to warrant positive selection of critically self-reactive clones; or (ii) IgD interferes with IgM signalling leading to modulation of ...
Circulating IgD can bind to myeloid cells such as basophils and induce antimicrobial, inflammatory, and B-cell-stimulating factors upon cross-linking, which contributes to immune surveillance but also inflammation and tissue damage when this pathway is overactivated under pathological conditions.
1 Ιουν 2011 · This study identified the cytokine signals that promote the CSR and production of human IgD, and the function of IgD in inducing immuno-activating, pro-inflammatory and antimicrobial functions of basophils.
28 Ιουν 2009 · Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell–dependent and T...
